Stevens-Johnson Syndrome (SJS) is a severe illness associated with fever and skin problems including rash, blisters, and ulcers. Although it can affect skin all over the body, a trademark of SJS are problems of the skin inside the mouth, nose, and eyes.

Blisters
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SJS is caused by an overreaction of the immune system to certain medications. It is not certain what causes the overreaction but it may be linked to genetic factors.